Polystyrene Nanoplastic Exposure Promotes Amyloid Misfolding and Metabolic Impairment at Sub-Lethal Doses. A Subcellular Infrared Imaging Study

Key Points

• This research aims to explore how exposure to polystyrene nanoplastics influences amyloid misfolding and metabolic processes.
• Utilized subcellular infrared imaging techniques.
• Assessed amyloid misfolding at various concentrations of polystyrene nanoplastics.
• Evaluated metabolic impairment in cells exposed to nanoplastic particles.
• Exposure to polystyrene nanoplastics induced significant amyloid misfolding.
• Metabolic impairment was observed even at sub-lethal doses.
• Findings suggest a direct link between nanoplastic exposure and neurotoxic effects.