What question did this study set out to answer?

This research aims to investigate the connectivity of thalamic subnuclei in individuals with major depressive disorder (MDD).

March 13, 2026Open Access

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Functional and structural connectivity of thalamic subnuclei in major depressive disorder at 7 Tesla

WLWeijian LiuChinese Academy of Medical Sciences & Peking Union Medical College SLS. LiuKunming Institute of Zoology JHJurjen HeijNetherlands Institute for Neuroscience

Key Points

This research aims to investigate the connectivity of thalamic subnuclei in individuals with major depressive disorder (MDD).
Used 7 Tesla MRI for high-resolution imaging of thalamic subnuclei
Analyzed connectivity patterns with cortical and subcortical regions
Compared findings between individuals with MDD and healthy controls
Increased thalamic connectivity observed in individuals with MDD
Specific subnuclei showed distinct connectivity patterns related to depression
Findings suggest a link between thalamic subnuclear activity and MDD symptoms

Abstract

Thalamic subnuclear connectivity with cortical and subcortical brain regions is perturbed in MDD. These results further support increased thalamic connectivity in MDD and suggest that this is related to a specific subnucleus.

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Functional and structural connectivity of thalamic subnuclei in major depressive disorder at 7 Tesla

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Abstract

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