This paper proposes the Stress-Adaptation Co-Evolutionary Hypothesis (SACE), which posits that South American botanical species adapted to extreme environmental conditions — high ultraviolet irradiance in the Andean-Patagonian plateau and oxidative-flooding stress cycles in the Amazonian floodplain — developed secondary metabolite profiles of exceptional antioxidant and anti-inflammatory potency as a direct result of evolutionary selection pressure. Seven species across two terroir lines are systematically examined: the Patagonian Line (Aristotelia chilensis, Berberis microphylla, Rosa rubiginosa) and the Amazonian Line (Euterpe oleracea, Myrciaria dubia, Mauritia flexuosa, Copaifera spp.), characterized by primary bioactive compounds, documented cutaneous mechanisms, and ORAC antioxidant indices demonstrating a 2–4× advantage over temperate equivalents. The ICDT (Index of Dermotherapeutic Compatibility) is proposed as a translational scoring framework mapping phytochemical profiles to individual systemic phenotypes. The SACE framework constitutes the first formal co-evolutionary rationale applied to botanical ingredient selection in dermatological personalized protocols within the Fitodermonutrição™ field.
Willer de Souza (Wed,) studied this question.