Histopathological and molecular features of adenomatous and serrated colon adenomas, characteristics and overlapping features, challenges in the nomenclature

Key Points

• The aim is to explore the overlapping histopathological and molecular features of adenomatous and serrated colon adenomas.
• Analyzed histopathological characteristics of adenomatous and serrated colon adenomas.
• Assessed the application of quantitative thresholds.
• Evaluated interobserver variability in diagnosis.
• Identified overlapping histopathological features among adenoma types.
• No single histopathological feature was specific to any lesion type.
• Using quantitative thresholds improved diagnostic accuracy and reduced variability.