ABSTRACT Aim Secretory carcinoma (SC), also known as mammary analogue secretory carcinoma, is a rare malignant neoplasm of the salivary glands, named for its histological and molecular resemblance to mammary secretory carcinoma. The aim of this study is to present a new case of SC occurring in the lower lip, initially diagnosed as a mucocele, and to provide a comprehensive review of reported cases in minor salivary glands. Materials and Methods A 40‐year‐old woman presented with a nodular lesion of the lower lip clinically diagnosed as a mucocele. An excisional biopsy was performed, and histopathological and immunohistochemical analyses confirmed the diagnosis of SC. The patient was referred to an oncology referral centre for therapeutic planning. In addition, a literature review was performed. Results Identifying 55 articles published between 2010 and 2025 and documenting 96 cases of SC in minor salivary glands. SC showed a slight female predominance (48.9%, n = 47), with a mean age of 46.27 ± 17.47 years, and most commonly affected the lip (34.3%, n = 33). Local recurrence (44.7%, n = 43) and metastasis (41.6%, n = 40) were infrequently reported, and most patients remained alive without evidence of disease at follow‐up (55.2%, n = 53). Conclusion SC is a rare malignant tumour with overlapping clinical and histological features that may mimic other soft tissue lesions. This case, combined with data from the literature, highlights the importance of considering SC in the differential diagnosis of nodular lesions of the oral mucosa and emphasises the need for accurate diagnosis and long‐term follow‐up.
Colares et al. (Tue,) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: