An imbalance between CD80 and CD86 levels and CD4 regulatory T cell number and transendocytosis function exists in the liver in autoimmune hepatitis.

Key Points

• Examine the relationship between Treg function and costimulatory molecules CD80/CD86 in the liver during autoimmune hepatitis (AIH).
• Analyzed Treg frequency and function in liver samples from AIH patients, including those with cirrhosis and liver failure.
• Assessed levels of CD80 and CD86 and their correlation with Treg activity.
• Evaluated the activated phenotype of hepatic Treg.
• No reduction in Treg frequency or transendocytosis function in cirrhotic liver or liver failure cases.
• Notable imbalance between Treg function and availability of CD80 and CD86.
• Increased activation of conventional T cells (Tcon) linked to excess CD80/CD86.