Loss of Pericyte Exacerbates Alzheimer's Disease‐Associated Retinal Pathology

Key Points

• This research focuses on understanding how the loss of retinal pericytes contributes to retinal pathology in Alzheimer's Disease.
• Analyzed retinal pathology in models of Alzheimer's Disease
• Assessed the impact of pericyte loss on Aβ and p-Tau accumulation
• Examined changes in retinal vascular structure and function
• Pericyte loss exacerbates Aβ and p-Tau pathology in the retina
• Evidenced increased retinal vascular damage and structural abnormalities
• Implicated the impairment of the ocular glymphatic system in these changes