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Neoadjuvant Immunotherapy and Chemoimmunotherapy Regimens in Head and Neck Cancer | Synapse

March 14, 2026JAMA Otolaryngology–Head & Neck Surgery0 citations

Neoadjuvant Immunotherapy and Chemoimmunotherapy Regimens in Head and Neck Cancer

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HBHannah Baratz CHC. Hidalgo DPDaniel L. Price

Key Points

This research aims to compare the efficacy of neoadjuvant chemoimmunotherapy regimens with immunotherapy alone in head and neck cancer.
Comparative analysis of neoadjuvant treatment regimens
Assessment of pathologic and radiographic response rates
Focus on locoregionally advanced head and neck squamous cell carcinoma (HNSCC)
Neoadjuvant chemoimmunotherapy regimens associated with higher pathologic response rates
Neoadjuvant chemoimmunotherapy regimens associated with higher radiographic response rates
Need for phase 3 trials to compare regimens head to head

Abstract

These findings suggest that neoadjuvant chemoimmunotherapy regimens were associated with higher pathologic and radiographic response rates compared with immunotherapy alone in locoregionally advanced HNSCC. These results call for phase 3 trials comparing these neoadjuvant regimens head to head.

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Cite This Study

Baratz et al. (Thu,) studied this question.

synapsesocial.com/papers/69b4b9eb18185d8a39802230 https://doi.org/https://doi.org/10.1001/jamaoto.2026.0080