What question did this study set out to answer?

To assess the relationship between TERT promoter methylation and gene expression in glioblastoma.

March 14, 2026Neurology India0 citationsOpen Access

TERT Promoter Methylation in Glioblastoma and its Paradoxical Association with Upregulated Gene Expression

SPSuvendu Purkait ASAman Swami PDPotnuru Gouri Shankar Das

Key Points

To assess the relationship between TERT promoter methylation and gene expression in glioblastoma.
Evaluated TERT promoter methylation status in glioblastoma within an Indian cohort.
Analyzed the association between methylation and gene expression levels.
Considered implications for therapeutic targets involving demethylating agents.
TERT promoter methylation is significantly associated with increased gene expression in glioblastoma.
Findings support the notion that TERT hyper-methylation is involved in the pathobiology of GBM.
Study proposes potential therapeutic targeting of epigenetic alterations in GBM.

Abstract

The present study is the first to assess the TERT promoter methylation status in GBM in an Indian cohort. TERT hyper-methylation is crucially implicated in the pathobiology of GBM by enhancing the gene expression. This epigenetic alteration may be an important therapeutic target, especially with the use of a specific demethylating agent.

اسأل الذكاء الاصطناعي

Bookmark

View Full Paper