• A novel approach to rehabilitating an 18-year-old patient with Papillon–Lefèvre Syndrome (PLS) using digitally planned, 3D-printed subperiosteal implants in both jaws. • The technique avoided the need for bone grafting, offering a bone-preserving alternative to conventional implants in a patient with severe jawbone atrophy. • Treatment involved single-surgery placement of custom titanium frameworks and immediate loading with fixed screw-retained prostheses. • Short-term outcomes were highly successful, with significant improvements in function, aesthetics, and patient satisfaction, and no early complications. • While promising, the approach requires long-term validation; careful patient selection and meticulous surgical and prosthetic planning are critical due to historical risks of exposure and infection. Papillon–Lefèvre syndrome (PLS) leads to early edentulism and severe alveolar atrophy, complicating prosthetic rehabilitation. Conventional implants often require extensive grafting and are contraindicated in growing patients. Subperiosteal implants, revitalized by digital dentistry, offer a bone-preserving alternative, though their use in PLS remains scarcely documented. An 18-year-old edentulous female with PLS underwent full-arch rehabilitation using digitally planned, additively manufactured subperiosteal implants in both jaws. CBCT and CAD/CAM guided the design of patient-specific titanium frameworks, which were surgically placed and immediately loaded with screw-retained metal-ceramic prostheses. The case illustrates that modern subperiosteal implants can successfully rehabilitate severe atrophy without bone grafting, offering functional and aesthetic improvement. Key considerations include soft tissue management, transmucosal interface stability, and the need for long-term maintenance. Despite promising short-term outcomes, historical concerns regarding exposure and infection underscore the importance of careful planning and follow-up. Digitally fabricated subperiosteal implants present a viable, graft-free solution for PLS-related edentulism, with favorable short-term results. This approach expands rehabilitative options for young patients with severe bone loss, though long-term studies are essential to establish its durability and refine clinical indications.
Jaddoua et al. (Sun,) studied this question.