Controllable synthesis of large-sized single-crystal covalent organic frameworks

Key Points

• To explore strategies for the controllable synthesis of large single-crystal covalent organic frameworks (COFs).
• Review of synthesis strategies including regulation agents, seed method, interfacial synthesis, and supercritical CO2 synthesis.
• Analysis of polymer reaction types, assembly pathways, feature blocks, and crystallization media for COFs.
• Discussion on iterative assembly methods and multi-level structural analysis.
• Identified critical roles of regulation strategies in discovering new COF structures and phenomena.
• Highlighted advances in the assembly process, aiding in precise structural analysis of large COFs.
• Outlined future trends for the development of complex assembly mechanisms and unique applications of synthesized crystals.