Inhaled 5‐ HT 1B / 1D Receptor Antagonist Attenuates Sumatriptan‐Induced Sensitization of Capsaicin‐Sensitive Lung Vagal Afferents: Implications for Preventing Sumatriptan‐Associated Adverse Chest Symptoms

Key Points

• To evaluate the efficacy of inhaled 5-HT1B/1D receptor antagonists in preventing sensitization and adverse symptoms associated with sumatriptan.
• Utilized models to assess the effects of inhaled 5-HT1B/1D antagonists on capsaisin-sensitive lung vagal afferents.
• Examined the antagonists’ ability to prevent the sensitization caused by sumatriptan without affecting its efficacy.
• Inhaled 5-HT1B/1D receptor antagonist attenuated sumatriptan-induced sensitization of capsaicin-sensitive lung vagal afferents.
• The intervention did not diminish the antimigraine efficacy of sumatriptan.