What question did this study set out to answer?

To investigate how ISGylation of GAPDH influences glycolytic control and energy metabolism.

March 14, 2026Open Access

Proteomics and tracer metabolomics link GAPDH ISGylation to glycolytic control

Key Points

To investigate how ISGylation of GAPDH influences glycolytic control and energy metabolism.
Used proteomics techniques to analyze metabolic pathways
Assessed the role of ISG15 in glycolytic regulation
Investigated the post-translational modification mechanisms of GAPDH
Identified GAPDH as a key metabolic checkpoint
Established a link between ISG15 and glycolytic control
Revealed post-translational mechanisms regulating energy metabolism

Abstract

These findings identify GAPDH as a central metabolic checkpoint regulated by ISGylation and uncover a direct post-translational mechanism by which ISG15 controls energy metabolism.

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