Multifunctional γ-Fe2O3/ZIF-8 Composite for Combined Magnetic Hyperthermia and 177Lu/161Tb Radionuclide Therapy

Key Points

• The research aims to create a multifunctional composite for integrating magnetic hyperthermia with radionuclide therapy.
• Engineered γ-Fe2O3/ZIF-8 hybrid nanostructures as theranostic platforms.
• Utilized a seed-mediated growth route for synthesis.
• Combined therapies of magnetic hyperthermia and dual-radionuclide treatment using 177Lu and 161Tb.
• Successfully synthesized composites showed potential for magnetic hyperthermia.
• Radionuclide therapy efficacy was enhanced when combined with magnetic hyperthermia.
• Demonstrated multifunctionality in targeted cancer treatment.