Goal directed perfusion (GDP) aims to maintain an O2 delivery above 270-300 ml/min/m2, during cardiopulmonary bypass. This strategy decreases the incidence of postoperative acute kidney injury. We first developed a simple physiological hypothesis that explained why maintaining an indexed DO2 above 280-300 ml/min/m2 could optimize organ protection during bypass, then we propose to tailor the O2 supply to patient real time VO2 as an individualized strategy, to optimize supply to metabolism need.
Diop et al. (Tue,) studied this question.
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