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NMD takes two PIN domains to tango | Synapse

March 14, 2026

NMD takes two PIN domains to tango

Key Points

To investigate the interaction between PIN domains of SMG5 and SMG6 and their role in NMD.
Analysis of protein interactions between SMG5 and SMG6.
Examination of physiological endonucleolytic activity.
Assessment of nonsense mRNA degradation initiating mechanisms.
Establishment of interaction between SMG5 and SMG6 PIN domains.
Identification of a composite catalytic site essential for nonsense mRNA decay.
Confirmation of physiological endonucleolytic activity in initiating degradation.

Abstract

Three new studies (Arpa et al. 2026; Kurscheidt et al. 2026; Modena et al. 2026) found that the PIN domains of SMG5 and SMG6, two proteins involved in nonsense-mediated mRNA decay (NMD), interact and show that the physiological endonucleolytic activity initiating the degradation of the nonsense mRNA is exerted by this composite catalytic site.

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Cite This Study

Muhlemann et al. (Wed,) studied this question.

synapsesocial.com/papers/69b4fb8db39f7826a300bd4e https://doi.org/https://doi.org/10.1261/rna.081027.126