L -Ergothioneine Attenuates Nephrolithiasis by Modulating Redox Signaling and Mitochondrial Function in Cystine and Calcium Oxalate Models

Key Points

• The research aims to evaluate the effectiveness of l-ergothioneine in reducing nephrolithiasis by targeting oxidative stress and mitochondrial dysfunction.
• Examined the effects of l-ergothioneine on oxidative stress in various nephrolithiasis models.
• Assessed mitochondrial function in the presence of l-ergothioneine.
• Compared outcomes with standard treatments for nephrolithiasis.
• l-Ergothioneine significantly reduced markers of oxidative stress in both cystine and calcium oxalate models.
• Improvement in mitochondrial function was observed with l-ergothioneine treatment.
• The findings indicate that l-ergothioneine could enhance existing therapies for nephrolithiasis.