Mechanistic insights into mitigation of sepsis-induced acute lung injury by quercitrin via TLR4/MAPK pathway inhibition

Key Points

• To explore how quercitrin mitigates sepsis-induced acute lung injury through specific molecular pathways.
• Investigated the effects of quercitrin on LPS-induced acute lung injury.
• Analyzed inflammatory responses and oxidative stress levels.
• Examined the TLR4/MAPK signaling pathway's role in quercitrin's protective mechanism.
• Quercitrin significantly reduced inflammatory responses and oxidative stress in models of acute lung injury.
• Inhibition of the TLR4/MAPK pathway was key to the protective effects observed.
• The findings suggest quercitrin may be a viable therapeutic option for sepsis-related acute lung injury.