Decoding Links between Gut Microbiota and Metabolic-associated Fatty Liver Disease: Meta-analysis and Mediation Study Uncover Species-specific Taxa and a Novel Bile Acid Mediator.

Key Points

• The research aims to explore the relationships between gut microbiota and metabolic-associated fatty liver disease (MAFLD).
• Conducted a meta-analysis to assess gut microbiota composition in MAFLD cases.
• Identified species-specific taxa linked to MAFLD.
• Investigated the role of bile acids in mediating these effects.
• Highlighted significant connections between specific gut microbiota and MAFLD.
• Uncovered potential therapeutic targets for treating MAFLD through modulation of gut microbiota.
• Identified novel bile acid mediators associated with disease pathogenesis.