In December 2019, a series of acute respiratory illnesses characterized by rapid worsening of symptoms, pneumonia, acute respiratory distress syndrome (ARDS), and in some cases, death were observed in Wuhan City, Hubei Province, China. To achieve the set objective, the results of treatment of 100 sexually mature rats of both sexes with coronavirus infection caused by COVID -19 were analyzed. All animals were divided into groups: Group 1 - animals with coronavirus infection with a confirmed positive PCR test, treated with ivermectin at a dosage of 300 mg of body weight (n = 25), Group 2 - animals with coronavirus infection treated with baicalin at a dosage of 500 mg (n = 25), Group 3 - animals with coronavirus infection treated with molnupiravir 25 mg / kg of body weight (n = 25), Group 4 - animals with coronavirus infection treated with a new drug based on G. lucidum and black cumin (n = 25). Lymphocytic myocarditis was detected in all rats (100%). Dystrophic changes in cardiomyocytes were also detected in 57.4% of cases, apoptotic bodies in 29.41% of cases, uneven cardiomyocyte hypertrophy in 85.29% of cases, and lipofuscinosis in 45.59% of cases. Subendocardial lipomatosis in the cardiac conduction system was observed in 51.47% of cases. The average percentage of lipomatosis area from the micrograph area was 2.47±3.12%. The area under the curve (AUC) = 0.91 (95% CI = 0.85-0.98). The prediction accuracy of the prognostic model was 91.7%, sensitivity was 0.87%, and specificity was 0.95%. AUC was 0.91 (95% CI = 0.85-0.98), p 0.001.
Abilov Mеlisovich (Tue,) studied this question.