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This research examines the role of Trefoil Factor-3 (TFF3) in promoting tumor activity in hepatoblastoma under hypoxic conditions.

March 15, 2026Open Access

Trefoil Factor‐3 Is a Hypoxia‐Triggered Pro‐Tumorigenic Factor in Hepatoblastoma

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Key Points

This research examines the role of Trefoil Factor-3 (TFF3) in promoting tumor activity in hepatoblastoma under hypoxic conditions.
Investigated TFF3's role as a hypoxia-inducible factor in hepatoblastoma cells.
Analyzed effects on cell proliferation, survival, and chemoresistance.
Examined the involvement of C-MYC and mTOR pathways.
TFF3 enhances proliferation and survival of hepatoblastoma cells under hypoxia.
Demonstrated increased chemoresistance in the presence of TFF3.
Identified TFF3 as a potential therapeutic target and circulating biomarker.

Abstract

TFF3 is a hypoxia-inducible factor that enhances HB cell proliferation, survival and chemoresistance. Its tumour-promoting activity through C-MYC and mTOR pathways identifies TFF3 as a potential therapeutic target and circulating biomarker in hepatoblastoma.

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Authors

Luz Andrea Martínez‐Pérez

Universidad de Guadalajara

M. Ujue Latasa

Navarre Institute of Health Research

Iker Uriarte

Instituto de Salud Carlos III

Journals

Liver International

Actions

Institutions

RWTH Aachen University

University of Turin

Charles University

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Trefoil Factor‐3 Is a Hypoxia‐Triggered Pro‐Tumorigenic Factor in Hepatoblastoma

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Abstract

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