March 15, 2026Open Access

The Association of Iatrogenic Withdrawal With Opioid and Benzodiazepine Weaning in Children With Bronchiolitis: A Single-Center, Retrospective Cohort Study, 2012–2022

Key Points

To investigate the association of iatrogenic withdrawal with opioid and benzodiazepine weaning in children with bronchiolitis.
Single-center, retrospective cohort study from 2012 to 2022
Analysis of cumulative IV opioid dose and weaning protocols
Assessment of withdrawal risk based on CCC-V2 categories
Higher cumulative IV opioid doses linked to increased withdrawal odds
Recent IV opioid weaning within 8-12 hours correlated with withdrawal
Morphine usage associated with significantly higher odds of withdrawal

Abstract

Patients with a higher cumulative IV opioid dose, an IV opioid wean in the preceding 8-12 hours, and greater than or equal to 2 CCC-V2 categories had the highest odds of withdrawal in this single-center study. Morphine was associated with increased odds of withdrawal as well.

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Cite this study

Shanklin et al. (Sun,) studied this question.

synapsesocial.com/papers/69b6069b83145bc643d1c9dd — DOI: https://doi.org/10.1097/cce.0000000000001391

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Authors

Alice Shanklin

Children's National

Eduardo A. Trujillo Rivera

Murray M. Pollack

George Washington University Hospital

Journals

Critical Care Explorations

Actions

Institutions

George Washington University

Children's National

Cohen Children's Medical Center

References and Citations

Connected Papers

Building similarity graph...

Analyzing shared references across papers

The Association of Iatrogenic Withdrawal With Opioid and Benzodiazepine Weaning in Children With Bronchiolitis: A Single-Center, Retrospective Cohort Study, 2012–2022

Key Points

Abstract

Citation Network

Connected Papers

Discussion

Cite this study

Also consider

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

Also consider