Lewis Acid-Mediated Formamidation Employing Carbohydrates as Synthons

Key Points

• The aim was to develop a practical formamidation method utilizing carbohydrates as synthons.
• Developed a formamidation method using air as the sole oxidant.
• Utilized a Lewis acid as the catalyst for the reaction.
• Eliminated the need for exogenous oxidants or stoichiometric additives.
• Successfully performed formamidation using carbohydrates.
• Showed the viability of air as the oxidant in the process.