State-Dependent Fornix-Hippocampal Communication and the Impact of Deep Brain Stimulation: Insights from Supervised Learning, Granger Causality and Causal Discovery Analyses

Key Points

• The research aims to examine how deep brain stimulation affects communication within the fornix-hippocampal network.
• Analyzed the effects of continuous fornix deep brain stimulation (DBS) on communication pathways.
• Used supervised learning techniques to evaluate network interactions.
• Employed Granger causality and causal discovery analyses to assess bidirectional communication.
• Continuous fornix DBS disrupts the normal communication within the fornix-hippocampal network.
• This disruption may explain the limited success observed in clinical applications.
• Adaptive stimulation strategies may help maintain endogenous functionality for better therapeutic results.