MM-VCM enables efficient preanalytic corrections for bacterial loads, supporting diagnostics where resampling is infeasible (e.g., CSF, high-volume labs). Empirical validation against a multicenter clinical blood culture dataset at 25 °C revealed that model predictions broadly corresponded with observed detection patterns for S. aureus and S. pneumoniae, with greater variability observed for E. coli, supporting the model's potential utility pending further validation.
Mahrizi et al. (Sun,) studied this question.