Introduction The Achilles tendon (AT) is vital for sports performance yet highly susceptible to injury. Exercise can induce structural and mechanical adaptations, but the relative effectiveness of different protocols remains uncertain. This systematic review and network meta-analysis evaluated exercise-based interventions targeting AT morphology and mechanics in healthy adults. Methods PubMed, Web of Science and Scopus were searched from inception to 18 Feb 2025. Randomized controlled trials (RCTs) were synthesized using random-effects network meta-analysis (Hedges' g). Risk of bias was assessed using a modified Downs and Black Quality Index. Results Forty-nine trials were included in the systematic review; 31 RCTs ( n = 1,388) contributed to the network across five intervention categories (15 subtypes). Short-term plyometric jump training ranked highest for increasing AT cross-sectional area (SUCRA 95.6%; SMD 1.33 vs. control). Long-term isometric plantar-flexion training ranked highest for improving stiffness (SUCRA 89.3%). Gait retraining ranked highest for AT length, elongation and strain (SUCRA 59.6%–77.1%), although networks for several outcomes were sparse and estimates imprecise. Stretching-focused programs generally ranked low across outcomes. Discussion In healthy adults, progressive, higher-dose loading, particularly isometric plantar-flexion training and plyometric jump training, shows the most favorable rankings for AT adaptation. Rankings should be interpreted cautiously given heterogeneity and sparse networks for some outcomes; well-powered head-to-head RCTs with harmonised outcome definitions are needed. Systematic Review Registration https://www.crd.york.ac.uk/prospero , PROSPERO CRD420251009672.
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