What question did this study set out to answer?

This research aims to identify stroke risk factors in pediatric patients with sickle cell disease and moyamoya arteriopathy.

March 16, 2026

Understanding stroke risk phenotypes in pediatric patients with sickle cell disease and concurrent moyamoya arteriopathy: insights from 61 cases at a single institution

Key Points

This research aims to identify stroke risk factors in pediatric patients with sickle cell disease and moyamoya arteriopathy.
Analysis of 61 pediatric cases from a single institution
Comparison of stroke incidence in children with HbSS and those with concurrent MMA
Assessment of neurological deficits post-stroke
Children with HbSS and MMA exhibit higher stroke risk early in childhood
Delayed diagnosis of stroke is common in patients with HbSS and MMA
Recommendations for stroke prevention screening in children aged 3-8 years.

Abstract

Children with HbSS and concurrent MMA have increased risk of stroke during early childhood relative to children with HbSS alone. Additionally, those with HbSS and MMA are at risk of delayed diagnosis after experiencing neurological deficit from symptomatic stroke. These findings represent an opportunity to optimize stroke prevention screening, targeting children as young as 3-8 years of age.

Understanding stroke risk phenotypes in pediatric patients with sickle cell disease and concurrent moyamoya arteriopathy: insights from 61 cases at a single institution

Key Points

Abstract

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