What does this research mean for the field?

Primary melanoma of the liver can occur without an identifiable primary site, as demonstrated in a case of a 69-year-old patient. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To highlight the rarity of primary hepatic melanoma through a detailed case examination.

March 16, 2026Open Access

Primary Hepatic Melanoma: A Case Report

MBMohammed Zoheir BakhtiCentre Hospitalier Universitaire Mohammed VI CBChaimae BekhakhCentre Hospitalier Universitaire Mohammed VI AHAnass HalouiCentre Hospitalier Universitaire Mohammed VI

Key Points

To highlight the rarity of primary hepatic melanoma through a detailed case examination.
Presented a case of a 69-year-old patient with hepatic nodular lesions.
Conducted radiological examinations suggesting hepatocellular carcinoma.
Performed a biopsy of the nodular lesion for histopathological analysis.
Used immunohistochemical analysis with anti-SOX10, anti-Melan A, and anti-HMB45 antibodies.
Diagnosis of an undifferentiated malignant tumor was established from the biopsy.
Immunohistochemical analysis confirmed the melanocytic origin of the tumor.
Further examinations to locate the primary site of melanoma were negative.

Abstract

Primary melanoma of the liver is very rare, with only a few cases reported. We present a 69-year-old patient with no significant medical history, admitted for the discovery of hepatic nodular lesions whose radiological examination suggested hepatocellular carcinoma. The biopsy of the nodular lesion revealed an undifferentiated malignant tumor, and immunohistochemical analysis using anti-SOX10, anti-Melan A, and anti-HMB45 antibodies confirmed melanocytic origin. Subsequently, the patient underwent additional examinations to search for the primary site, which were negative. Ultimately, the diagnosis of a primary melanoma of the liver was established.

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