Greater adherence to a gut microbiota-supportive diet (DI-GM score ≥6) was associated with significantly reduced odds of hypertension (adjusted OR 0.73) compared to lower adherence (score 0-3).
Cross-Sectional (n=20,905)
Yes
Does higher adherence to a gut microbiota-supportive dietary pattern reduce the prevalence of hypertension in U.S. adults?
Higher adherence to a gut microbiota-supportive dietary pattern is independently associated with a lower prevalence of hypertension in U.S. adults.
Effect estimate: OR 0.73 (95% CI 0.66-0.78)
Emerging evidence underscores the role of gut microbiota as a critical regulator of cardiometabolic health, particularly in blood pressure modulation. Although dietary habits are known to influence microbial diversity and function, the association between microbiota-supportive dietary patterns and hypertension remains insufficiently characterized. This study aimed to investigate the relationship between adherence to the Dietary Index for Gut Microbiota (DI-GM) and the prevalence of hypertension. We analyzed data from 20,905 participants in the 2010–2020 cycles of the National Health and Nutrition Examination Survey (NHANES). The DI-GM was derived from 14 dietary components either beneficial or detrimental to gut microbial balance. Multivariable logistic regression and restricted cubic spline models were employed to explore associations between DI-GM scores and hypertension. A higher DI-GM score was consistently associated with a lower likelihood of hypertension across all adjusted models. Compared to individuals with scores between 0 and 3, those scoring 6 or higher exhibited significantly reduced odds of hypertension (adjusted OR = 0.73; 95% CI 0.66–0.78). This inverse association was robust across all examined subgroups, with no statistically significant interactions detected. Greater adherence to gut microbiota-supportive dietary patterns, as reflected by higher DI-GM scores, was associated with a lower prevalence of hypertension among U.S. adults. These findings support the potential utility of microbiome-informed nutritional strategies in hypertension prevention and management.
Shen et al. (Sun,) conducted a cross-sectional in Hypertension (n=20,905). Dietary Index for Gut Microbiota (DI-GM) vs. DI-GM score 0-3 was evaluated on Hypertension prevalence (OR 0.73, 95% CI 0.66-0.78). Greater adherence to a gut microbiota-supportive diet (DI-GM score ≥6) was associated with significantly reduced odds of hypertension (adjusted OR 0.73) compared to lower adherence (score 0-3).