Synthesis and in vitro antitumor evaluation of novel 3,4-dihydropyrimidinone-vorinostat hybrids against gastric and breast cancer cell lines

Key Points

• The aim is to synthesize new compounds based on Vorinostat and evaluate their effectiveness against gastric and breast cancer cells.
• Synthesize DHPM–SAHA hybrids via the Biginelli reaction.
• Evaluate in vitro antitumor activity of synthesized compounds.
• Test against AGS gastric and MCF-7 breast cancer cell lines.
• New hybrids exhibit varying degrees of antitumor activity against AGS and MCF-7 cells.
• Some compounds show stronger effects than Vorinostat.