Photonic crystal waveguides (PhCWs) have emerged as a leading platform for integrated optical sensing due to their ability to engineer dispersion, enhance light–matter interaction, and exploit slow-light effects. This review provides a comprehensive analysis of the fundamental physics, performance metrics, device architectures, and application domains that define the current state of PhCW-based sensing. Key mechanisms governing sensitivity, figure of merit, detection limit, and dynamic range are examined, with emphasis on the intrinsic trade-offs introduced by slow-light operation, including disorder-induced scattering, linewidth broadening, and thermal susceptibility. Advances in dispersion engineering, such as hole shifting, gentle confinement, and width modulation, are highlighted alongside novel architectures including slot PhCWs, hybrid material platforms, and plasmonic–photonic configurations. Their respective capabilities in enhancing analyte overlap, improving spectral stability, and expanding functional integration are critically assessed. Emerging applications in biochemical detection, environmental monitoring, and nanoscale particle sensing further illustrate the versatility of PhCWs within modern optofluidic and lab-on-chip systems. The review concludes by outlining key challenges and future directions, including disorder-resilient slow-light design, inverse-engineered structures, and platform-level integration, which collectively chart a path toward next-generation high-performance photonic crystal sensing technologies.
Kazanskiy et al. (Mon,) studied this question.