What question did this study set out to answer?

To explore the therapeutic potential of GLP-1/apelin hybrid molecules for obesity and T2DM management.

March 18, 2026Open Access

Unimolecular GLP ‐1/Apelin Hybrid Peptides Cause Prominent Appetite Suppression, as Well as Enhancing Insulin Secretion, Beta‐Cell Survival and Glycaemic Regulation

Key Points

To explore the therapeutic potential of GLP-1/apelin hybrid molecules for obesity and T2DM management.
Designed and synthesized GLP-1/apelin hybrid peptides
Evaluated the effects on appetite and insulin secretion
Assessed beta-cell survival and glycaemic regulation
Hybrid peptides caused significant appetite suppression
Enhanced insulin secretion observed
Improved beta-cell survival and glycaemic regulation noted

Abstract

These studies highlight the clear therapeutic applicability of rationally designed GLP-1/apelin hybrid molecules for the treatment of obesity and T2DM.

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Cite this study

Sridhar et al. (Mon,) studied this question.

www.synapsesocial.com/papers/69ba42bc4e9516ffd37a350f — DOI: https://doi.org/10.1111/dom.70647

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Authors

Ananyaa Sridhar

Ethan Palmer

Sarah Craig

Journals

Diabetes Obesity and Metabolism

Actions

Institutions

University of Ulster

References and Citations

Connected Papers

Building similarity graph...

Analyzing shared references across papers

Unimolecular GLP ‐1/Apelin Hybrid Peptides Cause Prominent Appetite Suppression, as Well as Enhancing Insulin Secretion, Beta‐Cell Survival and Glycaemic Regulation

Key Points

Abstract

Citation Network

Connected Papers

Discussion

Cite this study

Also consider

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion