What question did this study set out to answer?

The study aims to explore the characteristics of shared T cell receptor (TCR) repertoire in response to viral antigens.

March 18, 2026

Differences in Shared T Cell receptor α Repertoire Associated with Recognition of Viral Antigens

Key Points

The study aims to explore the characteristics of shared T cell receptor (TCR) repertoire in response to viral antigens.
Identified novel shared TCR repertoire
Analyzed TCR selection processes
Investigated links to immune responses against HSV-2
Detected a unique type of shared TCR repertoire
Suggested this repertoire arises from selection rather than convergent recombination

Abstract

Our results identify a novel type of shared TCR repertoire, likely to be generated by selection instead of convergent recombination. Whether this reflects features exclusive to the immune response against HSV-2 remains to be studied.

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Discussion

Authors

Tiitus Lamponen

Joonatan Mattila

Nelli Heikkilä

Journals

Immunological Investigations

Actions

Institutions

University of Helsinki

University of Geneva

Aalto University

References and Citations

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Building similarity graph...

Analyzing shared references across papers

Differences in Shared T Cell receptor α Repertoire Associated with Recognition of Viral Antigens

Key Points

Abstract

Citation Network

Connected Papers

Discussion

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

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