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Research Paper | Synapse

March 18, 2026

Clarifying the SOFA-2 Score

Key Points

The aim is to clarify and validate the SOFA-2 score, an updated organ dysfunction index used in critical care.
Development of the SOFA-2 score
Validation against clinical data
Comparison with previous indices
The SOFA-2 score demonstrates improved accuracy in assessing organ dysfunction
Enhanced bedside assessment capabilities
Better alignment with clinical research needs.

Abstract

To the Editor Dr Ranzani and colleagues describe the development and validation of the SOFA-2 score, a major update of an organ dysfunction index central to both clinical research and bedside assessment in critical care medicine.1

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Authors

C

C. Monard

Hospices Civils de Lyon

A

Antoine Schneider

University Hospital of Lausanne

Journals

JAMA

Actions

Institutions

University of Lausanne

University Hospital of Lausanne

Hospices Civils de Lyon

References and Citations

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Cite this study

Monard et al. (Mon,) studied this question.

synapsesocial.com/papers/69ba434a4e9516ffd37a4518 — DOI: https://doi.org/10.1001/jama.2026.0304