Effects of subcutaneous and sublingual allergen immunotherapy on immune responses in children with bronchial asthma.

Key Points

• This research aims to compare the effects of subcutaneous (SCIT) and sublingual (SLIT) allergen immunotherapy on immune responses in children with bronchial asthma.
• Compared efficacy of SCIT and SLIT combined with inhaled corticosteroids (ICS) against ICS monotherapy.
• Examined immunological changes associated with both therapies.
• Analyzed Treg cell induction as a potential mechanism of immunity.
• SCIT and SLIT combined with ICS showed superior efficacy to ICS alone.
• Both therapies induced comparable immunological changes, indicating a similar mechanism of action.
• Evidence suggests Treg cell induction plays a role in achieving immune tolerance.