Temporal Modeling of Amyloid and Tau Trajectories in Alzheimer's Disease Using PET and Plasma Biomarkers

Key Points

• To evaluate how well plasma biomarkers can model the progression of amyloid and tau in Alzheimer's Disease compared to traditional PET imaging.
• Used plasma biomarkers for temporal modeling of amyloid and tau trajectories.
• Compared biomarker data with PET imaging results.
• Assessed biological disease severity using the models.
• Plasma biomarker modeling provides insights similar to PET imaging.
• Tau onset age was accurately predicted using plasma data.
• The approach can enhance clinical assessments of Alzheimer's Disease.