Tuning Donor Ability of Oxygen with Inverse α-Effect: Two Levels of Kinetic Control Open Access to Four Classes of Peroxygenated Heterocycles

Key Points

• The study aims to investigate the effects of acid and hydrogen peroxide loadings on the formation of cyclic peroxides from diketones.
• Utilized acid-catalyzed reactions with hydrogen peroxide
• Explored loadings of acid and peroxide to control reaction pathways
• Synthesize various oxygen-rich cyclic peroxides from common 1,4-diketone precursors
• Successfully produced diverse classes of cyclic peroxides
• Achieved precise control over the reaction outcomes with varying conditions
• Demonstrated a new approach to synthetic pathways for oxygen-rich compounds