A novel room-temperature CQD fluorescent nanosensor for the first derivatization-free spectrofluorimetric determination of dalfampridine: application to biological fluids and content uniformity testing

Key Points

• This research aims to develop a novel fluorescent nanosensor for detecting dalfampridine without prior chemical modification.
• Synthesis of room-temperature carbon quantum dots using hydroquinone and monosodium glutamate.
• Use of fluorescent RT-CQDs as a nanoprobe for spectrofluorimetric analysis.
• Application of the sensor in analyzing dalfampridine in pharmaceuticals and human plasma.
• Demonstrated high sensitivity in detecting dalfampridine using the RT-CQDs device.
• Effective application in biological fluids and ensuring content uniformity in pharmaceuticals.