What question did this study set out to answer?

To highlight the diagnostic challenges posed by stable pleural effusion in Meigs syndrome, particularly in the context of a benign Brenner tumor.

March 19, 2026Open Access

Stable Pleural Effusion as a Diagnostic Pitfall in Meigs Syndrome: A Case of a Benign Brenner Tumor with Elevated CA125

Key Points

To highlight the diagnostic challenges posed by stable pleural effusion in Meigs syndrome, particularly in the context of a benign Brenner tumor.
Case report of a 74-year-old woman with Meigs syndrome
Evaluation based on imaging and CA125 levels
Focus on the clinical progression of symptoms
Initial diagnosis delayed due to persistent stable exudative pleural effusion
Imaging revealed a large pelvic mass after worsening symptoms
CA125 levels elevated, guiding the eventual diagnosis
Tumor resection led to complete resolution of fluid collection

Abstract

We report a rare case of Meigs' syndrome caused by a benign Brenner tumor in a 74-year-old woman. The diagnosis was delayed because of a one-year history of unexplained, persistently stable exudative pleural effusion. The subsequent worsening of effusion and new-onset ascites prompted imaging, which revealed a large pelvic mass and elevated cancer antigen 125 levels. Tumor resection resulted in the complete resolution of the fluid collection. This case illustrates that Meigs' syndrome can present with indolent exudative effusion. Therefore, a thorough pelvic evaluation should be considered in postmenopausal women with unexplained pleural effusion to prevent any diagnostic delays.

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