The aim is to determine the relationship between CSF monoamine metabolites and cognitive decline in early Parkinson's disease.
Analysis of cerebrospinal fluid (CSF) metabolites
Longitudinal assessment of cognitive function
Assessment of baseline levels of DOPAC and HVA
Baseline CSF DOPAC levels are associated with cognitive decline
Baseline HVA levels also correlate with cognitive deterioration
Evidence suggests these metabolites can predict cognitive outcomes over time.
Abstract
Taken together, our results indicated that baseline CSF DOPAC and HVA may serve as promising longitudinal predictors of cognitive decline in patients with PD.
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CSF Monoamine Metabolites and Cognitive Trajectory in Early Parkinson's Disease | Synapse