Catechol functionalized polyguluronate enriched sodium alginate wetspun fibers with immobilized platelet lysate for diabetic wound healing

Key Points

• The study aims to evaluate the effectiveness of catechol-functionalized alginate fibers with platelet lysate in diabetic wound healing.
• Developed wet-spun fibers using catechol-functionalized alginate and PEG.
• Applied polydopamine coating for sustainability.
• Loaded fibers with platelet lysate and tested on diabetic mice.
• The dressing significantly increased fibroblast proliferation.
• Enhanced angiogenesis was observed in treated wounds.
• Accelerated wound healing time was reported in diabetic mice.