Health economic evaluations alongside adaptive platform trials: A systematic review.

Key Points

• This review examines the incorporation of economic evaluations within adaptive platform trials (APTs).
• Conducted a systematic review of health economic evaluations in APTs.
• Analyzed the prevalence of embedded economic evaluation plans in APTs.
• Evaluated the methodological approaches employed at the platform level.
• Approximately 20% of adaptive platform trials included embedded economic evaluation plans.
• Economic evaluations focused on outcomes beyond cost-effectiveness, including resource prioritization and data collection.
• Identified a trend towards centrally planned economic evaluation methods for improved efficiency.