Lamotrigine-induced Stevens–Johnson syndrome: a systematic review of case reports and case series

Key Points

• This review aims to compile cases of Stevens-Johnson syndrome linked to lamotrigine to assess risks and improve safety protocols.
• Conducted a systematic review of existing case reports and series.
• Analyzed data on lamotrigine dosages, symptom onset, and patient outcomes.
• Evaluated the need for standardized reporting and causality assessment.
• Identified multiple cases of Stevens-Johnson syndrome associated with lamotrigine use.
• Early recognition and careful dosage adjustment were crucial in preventing severe outcomes.
• Calls for improved education and reporting practices to ensure patient safety.