Crossing and metabolism of tyrosol and hydroxytyrosol by implementing an in vitro blood-brain barrier model of human primary cells

Key Points

• This research investigates how tyrosol and hydroxytyrosol interact with the blood-brain barrier and their potential neuroprotective effects.
• Utilized an in vitro model of the blood-brain barrier with human primary cells.
• Administered tyrosol and hydroxytyrosol to study their crossing and metabolism.
• Analyzed cellular responses to assess neuroprotective properties.
• Tyrosol and hydroxytyrosol effectively crossed the blood-brain barrier.
• Both compounds demonstrated neuroprotective effects in the tested model.
• Findings suggest olive oil consumption may confer neurological benefits.