Phase I trial of locoregional administration of autologous tumor-infiltrating lymphocytes in patients with uveal melanoma and liver metastases (the HAITILS trial)

Key Points

• The trial aims to assess the safety and efficacy of locoregional administration of autologous tumor-infiltrating lymphocytes in treating uveal melanoma with liver metastases.
• Conducted a Phase I trial
• Participants received autologous tumor-infiltrating lymphocytes
• Focused on locoregional administration to target liver metastases
• Monitored safety and treatment response
• Initial safety results appear promising
• Efficacy in reducing liver metastases is under evaluation
• Potential for immunotherapy as a viable treatment option for uveal melanoma