What question did this study set out to answer?

To evaluate the impact of bridging therapy on functional outcomes in patients with acute medium-large ischemic strokes.

March 21, 2026Open Access

Bridging Thrombolysis Before Endovascular Therapy Improves Functional Outcomes in Medium–large Core Stroke Within 4.5 Hours: A Multicenter Propensity-Matched Study

Key Points

To evaluate the impact of bridging therapy on functional outcomes in patients with acute medium-large ischemic strokes.
Conducted a multicenter propensity-matched study
Included patients with acute ischemic stroke and medium-large core
Compared bridging therapy combined with EVT against EVT alone
Bridging therapy resulted in better functional outcomes
No increase in symptomatic intracranial hemorrhage (sICH) was observed
Suggests safety and efficacy of bridging therapy warrant further investigation

Abstract

Our study suggests that bridging therapy in patients with acute medium-large ischemic core within 4.5 hours of onset results in better functional outcomes than EVT alone without increasing the sICH rate. Further studies are required to assess the safety and efficacy of bridging therapy.

Read Full Paperexternally

Bookmark

View Full Paper

Cite This Study

Nguyen et al. (Wed,) studied this question.

synapsesocial.com/papers/69be38ee6e48c4981c679b70 https://doi.org/https://doi.org/10.1159/000551531

Bookmark

View Full Paper