Platelet-rich plasma ameliorates knee osteoarthritis in rats by modulating the abundance of gut Lactobacillus murinus

Key Points

• This research aims to explore the effects of platelet-rich plasma and Lactobacillus murinus on knee osteoarthritis in rats.
• Administered platelet-rich plasma and Lactobacillus murinus to rats with knee osteoarthritis.
• Evaluated the effects on gut microbiota diversity and associated therapeutic outcomes.
• Compared the efficacy of combined treatments versus individual treatments.
• Combination treatment showed greater effectiveness in reducing knee osteoarthritis symptoms compared to individual therapies.
• Modulation of gut microbiota was observed, indicating a potential mechanism behind the therapeutic effects.