Abstract:: In recent years, the intranasal drug delivery system has emerged as a promising approach for improving therapeutic outcomes in managing psychotic disorders. Polymer-based nanoparticles have gained significant attention as carriers for intranasal drug delivery due to their adjustable physicochemical properties, sustained drug release capabilities, and potential to target specific brain regions. This review provides a comprehensive examination of the current research landscape on intranasal drug delivery using polymer-based nanoparticles for treating psychotic disorders. It covers various psychotic conditions and explains the mechanisms involved in transferring drugs from the nasal cavity to the brain. Key advances in nanoparticle formulation, including polymer selection, size optimization, and surface modification, are discussed in relation to their effects on enhancing drug stability, bioavailability, and brain targeting. Overall, the findings highlight the significant potential of intranasal delivery of polymer-based nanoparticles as an effective strategy for improving therapeutics. By showcasing recent developments, this review contributes to the evolving field of intranasal drug delivery and provides valuable guidance for researchers and clinicians pursuing modern treatments for psychotic disorders.
Rout et al. (Thu,) studied this question.