Characteristics and Clinical Significance of Myocardial Work in Cardiac Light-Chain Amyloidosis: Pressure-Volume Loop Analysis Based on Cardiac Magnetic Resonance

Key Points

• The aim is to evaluate the characteristics of myocardial work impairment in cardiac light-chain amyloidosis and its clinical significance.
• Noninvasive pressure-volume loop analysis via cardiac magnetic resonance (CMR)
• Assessment of left ventricular ejection fraction (LVEF)
• Evaluation of extracellular volume (ECV) for disease severity
• Comparative analysis of myocardial work and ECV for risk stratification
• Myocardial work impairment can be detected early despite preserved LVEF.
• Myocardial work reflects disease severity quantified by ECV.
• Myocardial work serves as an alternative risk stratification marker to ECV.