What question did this study set out to answer?

To describe a rare case of aortic valve destruction in a patient with microscopic polyangiitis and myeloperoxidase antibodies.

March 23, 2026Polskie Archiwum Medycyny Wewnętrznej0 citationsOpen Access

When rare matters: aortic valve destruction in myeloperoxidase antineutrophil cytoplasmic antibody–associated microscopic polyangiitis

KRKatarzyna Romejko KLKsymena Leśniak JHJulia Hanke

Key Points

To describe a rare case of aortic valve destruction in a patient with microscopic polyangiitis and myeloperoxidase antibodies.
Case report of a 55-year-old woman
Diagnosis based on the presence of anti-myeloperoxidase antibodies
Clinical assessment of symptoms including fever and weight loss
Identification of aortic valve destruction in the patient
Strongly positive anti-myeloperoxidase antibodies
Clinical presentation included constitutional symptoms like fever and weight loss

Abstract

Microscopic polyangiitis (MPA) is an ANCA-associated, pauci-immune necrotizing small-vessel vasculitis with multisystem involvement, most commonly renal, pulmonary, and cutaneous.Its clinical presentation is heterogeneous and often nonspecific, with constitutional symptoms such as fever, unintentional weight loss, and asthenia 1.We report the case of a 55-year-old woman with microscopic polyangiitis, diagnosed in October 2024 with the presence of strongly positive anti-myeloperoxidase antibodies (MPO-ANCA).

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